ROBO Receptor: A Protein Interacting with GPCR Family in Many Tissues

Target Name: Roundabout homolog receptor

NCBI ID: P48134

Roundabout homolog receptor

Other Name(s): ROBO receptor | ROBO

ROBO Receptor: A Protein Interacting with GPCR Family in Many Tissues

The Roundabout homolog receptor (ROBO receptor) is a protein that is expressed in many tissues throughout the body. It is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling. Members of the GPCR family include many hormone receptors, neurotransmitter receptors, and intracellular receptors.

ROBO receptor is a non-specific GPCR mainly expressed in nervous tissue, endocrine tissue, cardiovascular tissue and skin tissue. It plays an important role in the nervous system, such as regulating the excitability balance of neurons, neuronal growth and regeneration, and neuronal apoptosis. In endocrine tissues, ROBO receptors are also widely expressed and mainly regulate the secretion of thyroid, adrenal gland and insulin. In cardiovascular tissues, ROBO receptors are involved in regulating myocardial contractility and heart rate, and in skin tissues, they are involved in regulating the growth and regeneration of skin cells.

ROBO receptor is a ligand-binding receptor that transmits signals by binding to ligands. After the ligand binds to the receptor, it can activate the signal transduction pathway in the cell, thereby regulating the physiological functions of the cell. The mechanism of ROBO receptor ligand binding is specific. Different ligands bind to different receptors, thereby achieving selectivity for different receptors.

In drug research and development, ROBO receptors are widely used as drug targets. Some studies have shown that ROBO receptors have potential application value in the treatment of neurological diseases, endocrine system diseases, and cardiovascular diseases. For example, ROBO receptor antagonists have been developed to treat neurological disorders such as depression, anxiety, and Parkinson's disease. In addition, some studies have also shown that ROBO receptor agonists can enhance myocardial contractility and heart rate, thus having potential application value in the treatment of cardiovascular diseases.

ROBO receptors also have important application value in biomedical research. By studying the expression and function of ROBO receptors, we can better understand the pathogenesis of neurological and endocrine system diseases and provide ideas for the development of new treatments. It can also provide new ideas for drug development by studying the binding mode of ROBO receptors and ligands.

Protein Name: Roundabout Homolog Receptor (nonspecified Subtype)

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